Cancer genomics, biomarkers, precision oncology and translational evidence.
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Published in The Lancet. Oncology. Open the PubMed record for the abstract and publication details.
Background Precision oncology requires diagnostic sampling that delivers molecularly actionable material quickly and safely. In non-small cell lung cancer (NSCLC), core-needle biopsy (CNB) remains common. Yet fine-needle aspiration (FNA) has re-emerged with rapid on-site evaluation (ROSE), optimized cell blocks, and next-generation sequencing. The objective of this study was to compare the economic costs of FNA vers…
Nature Medicine, Published online: 30 September 2026; doi:10.1038/s41591-026-04705-y In the randomized phase 2b VIRAGE trial, patients with treatment-naive metastatic pancreatic cancer received the hyaluronidase-expressing oncolytic adenovirus zabilugene almadenorepvec (VCN-01) intravenously with gemcitabine and nab-paclitaxel (GnP) or GnP alone, showing that VCN-01 plus GnP led to prolonged overall survival.
Distinguishing early melanoma from borderline, atypical, or biologically intermediate melanocytic lesions remains one of the most consequential and urgent diagnostic challenges in dermato-oncology, since melanoma causes nearly 95% of skin cancer deaths. This narrative review establishes the biological relevance and evaluates the clinical maturity of mass spectrometry-based proteomics, with particular emphasis on spa…
Although genetic sequencing is routine in cancer care, translating a tumor's complex mutation profile into actionable treatment decisions remains a central challenge. MutationProjector is pretrained on a large corpus of genomic alterations across more than 30,000 tumors, integrated with extensive molecular knowledge. The resulting projection reveals a tumor's altered molecular pathways, facilitating model interpreta…
Nature Medicine, Published online: 01 October 2026; doi:10.1038/s41591-026-04677-z An updated pooled analysis of 3-year and 5-year survival and other outcome data of 1,038 patients with melanoma treated with neoadjuvant immune checkpoint inhibitors (ICIs), BRAF and MEK inhibitors (BRAF/MEKis), or a combination of ICIs and targeted therapies shows that ICI as monotherapy or in ICI combinations are superior to BRAF/ME…
Nature Medicine, Published online: 29 September 2026; doi:10.1038/s41591-026-04693-z In a phase 1 trial, inhibition of the Werner syndrome helicase (WRN) enzyme exploits a new synthetic lethal vulnerability in cancers with microsatellite instability, offering a new way to target these tumors beyond immune checkpoint inhibition.
Nature Medicine, Published online: 01 October 2026; doi:10.1038/s41591-026-04674-2 A randomized trial in individuals with type 2 diabetes probed the kidney-protective mechanisms of semaglutide using a range of techniques, including histology, multiparametric MRI and transcriptomics.
Published in Oncology reports. Open the PubMed record for the abstract and publication details.
Nature Genetics, Published online: 01 October 2026; doi:10.1038/s41588-026-02770-0 Liu et al. identify cis-regulatory elements that silence the embryonic ζ-globin gene in definitive erythroid cells. Gene-editing strategies reactivate ζ-globin expression to therapeutically relevant levels in mouse and human disease models.
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Nature Genetics, Published online: 30 September 2026; doi:10.1038/s41588-026-02768-8 KRAS-mutant lung cancers frequently develop resistance to targeted inhibition. This study demonstrates that lineage plasticity shapes oncogene dependence during response and resistance to KRAS inhibition, establishing new models of histologic transformation.
Published in Bulletin du cancer. Open the PubMed record for the abstract and publication details.
Cyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin-dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S-phase entry. In a broad spectrum of human malignancies-including breast, ovarian, gastric, and non-small cell lung cancers-amplification or overexpression of CCNE1 disrupts the orderly regulation o…
Nature Genetics, Published online: 30 September 2026; doi:10.1038/s41588-026-02758-w This study provides a single-cell atlas of 3′ untranslated region regulation in the human brain, pointing to molecular mechanisms for genetic variants contributing to Alzheimer’s disease, Parkinson’s disease and other brain disorders beyond gene expression.
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