Ephedra decoction, Mahuangtang (MHT), is a traditional herbal formula comprising Ephedrae sinica (ES), Prunus armeniaca (PA), Cinnamomum cassia(CC), and Glycyrrhiza uralensis (GU). MHT is used to treat colds, influenza, and other respiratory conditions. This study investigates the anticoronaviral effect of MHT and elucidates its mode of action and the active antiviral components of MHT. UHPLC-MS/MS analysis showed t…
BK polyomavirus (BKPyV) infection may lead to BKPyV-associated nephropathy (BKPyVAN) and subsequent graft loss in kidney transplant recipients. Experimental studies have suggested that glucocorticoids (GCs) may enhance BKPyV replication through a steroid-responsive element within the viral genome. However, clinical observations have not consistently supported this association, prompting re-investigation of the effec…
Codonopsis polysaccharides exhibit diverse biological activities, but their antiviral effects against the H1N1 influenza A virus and how these activities change after sulfation modification remains unclear. In this study, crude Codonopsis polysaccharide (COP) was obtained via water extraction and alcohol precipitation, and COP-1 (2.1 × 103 Da, β-D-(2 → 1)-fructan) was isolated and purified. Both COP and COP-1 were m…
Lichen planus (LP) is a persistent mucocutaneous disorder with an unclear cause. Recent findings indicate that LP may be an extrahepatic manifestation of Hepatitis C infection. The aim of this study was to assess the prevalence of hepatitis C among our lichen planus patients. This cross-sectional study was done in the Dermatology and Venereology Department of Bangladesh Medical University, Dhaka, Bangladesh from Jan…
End-stage renal disease (ESRD) patients receiving maintenance hemodialysis are at high risk of hepatitis B virus (HBV) infection and demonstrate inadequate immune response to vaccination. The objective of the study was to assess the antibody response (anti-HBs levels) of hepatitis B vaccinated maintenance hemodialysis patients. This cross-sectional observational analytical study was conducted at Marine City Medical…
DOI
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Authors
Gupta RD, Dutta PK, Islam MA, Saha RK, Dutta S, Khan SR.
Inflammation is a central host response against viral infections. However, accumulating evidence indicates that when excessive, misdirected, or unresolved, the inflammatory response becomes a driver of disease, ultimately contributing to tissue damage, dysfunction, and death. The proper termination of inflammation relies on the timely engagement of resolution programs, and pro-resolving mediators have been extensive…
Japanese encephalitis virus genotype V (JEV GV) has caused multiple cases of viral encephalitis in South Korea. We report a human case of JEV GV in China, confirmed by serology, sequencing, and quantitative reverse transcription PCR. We confirm JEV GV infection in China, highlighting the persistent threat of this virus.
In July 2024, we reported information on the initial human mpox cases in Uganda. Genomic characterization of clinically suspected cases (July-December 2024) revealed cocirculation of several monkeypox virus clade 1b clusters and varicella zoster virus. Our findings highlight the need to refine differential diagnoses by molecular techniques and strengthen surveillance.
The sensing of viral nucleic acid by pattern recognition receptors (PRRs) is essential for initiation of a type-I interferon response against infection. Intracellular DNA sensing PRRs are responsible for initiating innate immune responses to poxviruses and other double-stranded DNA viruses. Poxviruses, in turn, encode an armoury of immunomodulators that inhibit this host defence mechanism. DNA-dependent protein kina…
Oliveira, M.; Manna, P. T.; Rodrigues, D.; Chau, L. F.; Allport, T.; Wagner, E.; Brooks, H.; Skinner, M. A.; Giotis, E. S.; Chaplin, A. K.; Guabiraba, R.; Bryant, C. E.; Ferguson, B. J.
The fungal pathogen Pyricularia oryzae is notorious for causing blast disease in various important cereal crops, including wheat, rice, millet, and oat. Whole-genome-informed data on this pathogen are necessary to better understand the host adaptability of the fungus, including identifying key determinants of infection to enable more precise disease control. Here, we report highly contiguous genome sequences (using…